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Measuring Magnetic Nanoforces Under the Microscope

December 15, 2013

NanoScan specializes in the measurement of magnetic properties of materials at the nanoscale, using scanning probe microscopy. The Swiss company aims to achieve the best magnetic lateral resolution in direct space, with minimal time for measurement. To achieve this, its team of physicists, electrical engineers and software engineers develops the
company’s microscopes, from the mechanical parts to the electronics controller and the software, with the desire to provide high-resolution scanning probe microscopes that fulfill present and future analytical needs on nanometer-sized
surface structures.

Dr Raphaëlle Dianoux, NanoScan’s CEO, says: “Our aim was to establish a niche application, and that was magnetic force microscopy. Designed for research, development and quality control of magnetic storage media and other magnetic material, our product, the hr-MFM (high-resolution magnetic force microscope), is an analytical and quantitative magnetic imaging system.” For an imaging example, see the magnetic force microscopy image to the right of a commercial hard disk, taken with the hr-MFM. The single bits are clearly recongnizable as bright (dark) patterns magnetized in the direction opposite (parallel) to the tip magnetization. The high resolution of the microsccope reveals the slightly curved and even grainy substructure of the bits.

The article about NanoScan was published in the Journal "Magnetic Technology International 2013". For even more articles, check out  http://ukipme.com/pub-magnetics.php.


Synthesis of Anisotropic 3D Magnetic Microspheres

December 14, 2013

Navid Hakimi and others in Dae Kun Hwang's research group at Ryerson University, Toronto, Canada are masters of making strangely shaped three-dimensional anisotropic microparticles using a simple one-step microfluidic based method.

The method exploits the non-uniformity of the polymerizing UV light, UV absorption by opaque nanoparticles in the precursor solution, and discontinuous photomask patterns to make magnetic and non-magnetic microparticles in a two-dimensional microchannel. Numerical simulations of monomer conversion in the microfluidic channel are performed to predict the manufactured particle shape.

For more details, check out the article here: DOI: 10.1002/adma.201304378.


Magnetic Particle Workshop (IWMPI) 2013

November 29, 2013

The 3rd International Workshop on Magnetic Particle Imaging (IWMPI) was held in Berkeley, CA USA on March 23-24, 2013. This year, there were a total of 70 presentations (44 oral and 26 poster presentations), and 4 keynote speeches. Please see the Workshop Program for details.

The proceedings are now available online at IEEEXplore.

For those who were not able to attend the workshop, there are the videos of keynote speeches available online. Check it out here: http://iwmpi.berkeley.edu.

And then don't forget, the next meeting will come soon, in Berlin in March 2014!


Nanotherapeutic Shows Promise in Eliminating Lethal Tumors

November 27, 2013

Researchers have created a nanotherapeutic based on gold nanoparticles coated with nucleic acids (SNAs). It is capable of penetrating the blood-brain barrier and blocked the expression of a gene associated with tumor growth. Testing on mice, researchers found reduced Bcl2L12 expression and a lower burden of brain tumors without adverse side effects. SNAs could work in therapeutic gene regulation that could help address various types of disease, according to the study published in Science Translational Medicine.

Although these "spherical nucleic acids" are not magnetic, maybe we can do the same thing with very small magnetic nanoparticles. Try!


Nanomagnet-Based Removal of Digoxin and Lead from Living Rats

November 22, 2013

Inge Herrmann et al. reported the in vivo (rat) purification of blood from Pb and digoxin. For this TurboBeads were functionalized with an iminodiacetic acid-based chelator respectively a digoxin antibody FAB (digiFAB). In detail, the nanoparticles were injected into an extracorporeal purification process. The functionalized magnetic beads bound the harmful substances and the actual seperation took place with the help of an applied magnetic field. A 50 % drop of concentration of both lead and digoxin could be achieved as fast as 10 minutes.

Get the details here: Nanoscale 2013, 5, 8718. (DOI)

The same group also reported the in vitro purification of blood from endotoxins via polymyxin B-functioanlized highly magnetic TurboBeads. The nanoparticles were added to endotoxin spiked blood and were thereafter magnetically separated from the solution. The efficient removal of endotoxins from blood by this straight forward procedure was investigated by ELISA.

Adv. Healthcare Mater. 2013, 2 , 829–835. (DOI)


Special Issue about Magnetic Nanoparticle Hyperthermia

November 13, 2013

In 1957 an American surgeon, Robert Gilchrist ignited excitement by suggesting the possibility that cancer can be treated with magnetic nanoparticle hyperthermia. Magnetic nanoparticles provide unique capabilities for biomedical research and clinical applications, some of which have been realized within the past two or three years. Much greater potential exists, but challenges must be addressed.

A just published special issue of the International Journal of Hyperthermia brings together original research and review articles from leaders in the field whose contributions highlight recent progress and future directions for cancer research and therapy with magnetic iron oxide nanoparticles. Dr. Robert Ivkov did a great job at editing this issue (Volume 29, Number 8, December 2013).

Check out all the different articles here:

    http://informahealthcare.com.ezproxy.library.ubc.ca/toc/hth/29/8


Catalytic Nickel and Cobalt Nanowires

November 04, 2013

If we could convert sun power to hydrogen in an inexpensive and sustainable way, we would have an environmentally friendly fuel - forever! Steps are now taken towards this goal at Duke University by chemists Zuofeng Chen, Benjamin J. Wiley , and coworkers have. In one potentially low-cost method, sunlight enters a specially designed cell and triggers a multistep electrochemical process that begins with water oxidation on a catalyst surface. That reaction produces O2 and frees electrons and protons, which can be combined to yield H2 .
These photoelectrochemical cells often depend on indium tin oxide (ITO), a transparent, electrically conductive material, coated with a catalytic metal oxide. Because of its ability to serve as a transparent electrode, ITO is the go-to material for various photoelectrochemical processes. But indium and ITO are  expensive. In addition, the catalytic oxide layer reduces ITO’s light transmission and thus cell efficiency, and its conductivity falls with extended use. The Duke team developed copper nanowires coated with a shell of nickel or cobalt as successful replacement. Initial tests show that a mesh of this inexpensive, transparent, conductive material exhibits sustained water oxidation activity comparable to that of metal oxide films, but transmits nearly seven times more light. In addition, the material can be deposited on glass or plastic substrates via simple liquid-phase methods, which may lead to new types of robust, flexible photoelectrochemical cells and other devices. Check out the original paper here.


Magnetic Responsive Polymer Composite Materials

October 23, 2013

A very timely and complete review of magnetic responsive materials was just published in Chemical Society Reviews (DOI: 10.1039/c3cs60058k) by Julie Thévenot, Hugo Oliveira and Olivier Sandre in Sébastien Lecommandoux's lab at the University of Bordeaux.

Magnetic responsive materials are the topic of intense research due to their potential breakthrough applications in the biomedical, coatings, microfluidics and microelectronics fields. By merging magnetic and polymer materials one can obtain composites with exceptional magnetic responsive features. Magnetic actuation provides unique capabilities as it can be spatially and temporally controlled, and can additionally be operated externally to the system, providing a non-invasive approach to remote control.

The authors identified three classes of magnetic responsive composite materials, according to their activation mode and intended applications, which can be defined by the following aspects. (A) Their ability to be deformed (stretching, bending, rotation) upon exposure to a magnetic field. (B) The possibility of remotely dragging them to a targeted area, called magnetic guidance, which is particularly interesting for biomedical applications, including cell and biomolecule guidance and separation. (C) The opportunity to use magnetic induction for thermoresponsive polymer materials actuation, which has shown promising results for controlled drug release and shape memory devices. For each category, essential design parameters that allow fine-tuning of the properties of these magnetic responsive composites are presented using key examples.


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Last Modified: December 09, 2013 - Magneticmicrosphere.com 2013