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Cargo-Towing Fuel-Free Magnetic Nanoswimmers for Targeted Drug Delivery

June 25, 2012

Catalytic nanowire motors are of interest for biomedical applications including drug delivery and gene therapy due to their ability to pick up, tow, and release particles. For example, Joseph Wang and co-workers, University of California, San Diego, USA, recently demonstrated the guided transport of drug-loaded liposomes, pancreatic cancer cells, and nucleic acids by fuel-driven nanomotors. Despite the advances in cargo-towing by catalytic nanomotors, future ex-vivo and in-vivo biomedical transport applications require the use of biocompatible, fuel-free nanomotors.

Wang and co-workers now report magnetically driven (fuel-free) nanomotors. These two- or three-segment, flexible nanowire motors consist of a rotating magnetic nickel head (≈ 1.5 μm long), along with a flexible silver segment (≈ 4 μm long). They are able to pick-up and transport various drug carriers from a loading zone to a predetermined destination through a predefined route. The transport occurs at a rate order of magnitude faster than that expected from Brownian motion and they are among the fastest fuel-free synthetic nanomotors reported to date. Check details out here.


Magnetophoresis at the Nanoscale: Tracking of Magnetic Targeting Efficiency

June 24, 2012

Amanda Silva et al. in Claire Wilhelm's lab wrote an interesting article about investigating magnetic targeting efficiency at the nanoscale. For their magnetophoretic mobility measurements, they developed a simple chamber including a microtip as a magnetic attractor for use under bright field or fluorescence microscopy. Different sets of magnetic nanocontainers were produced and their magnetophoretic mobility was investigated. The combination of the analysis of Brownian motion together with the magnetophoretic mobility inferred both the size, the magnetophoretic velocity and the magnetic content of the nanocontainers.

Additionally, nanomagnetophoresis experiments under fluorescence microscopy provided information on the constitutive core/shell integrity of the nanocontainers and the co-internalization of a fluorescent cargo. To see for yourself, check out their paper here.


LinkedIn

June 21, 2012

David Kennedy from Ikotech LLC just informed me that the LinkedIn "Magnetic Particles Interest Group" has already grown to over 100 members in less than 30 days since he first set it up at the Minneapolis conference -- including over 20 organic connections from people that neither attended the recent conference nor have any connection to David. It thus seems that the LinkedIn "Magnetic Particles Interest Group" is a tool that can help promote our field, industry, and the Magnetic Carriers conferences.

Please consider joining the LinkedIn group and/or participating, posting, or promoting your activities or the activities of others in the field on this group site. Information for the group, including how to join, can be reached at this link.


Special Issue about Pharmaceutical Nanoparticles in Pharmaceutical Research

June 09, 2012

The May 2012 issue of Pharmaceutical Research is a theme issue about "Magnetic Nanoparticles for Biomedical Applications" edited by Alexander Pfeifer and Katrin Zimmermann from the Institute of Pharmacology and Toxicologie, University of Bonn; und Christian Plank from the Institute of Experimental Oncology and Therapy Research at the Technical University in Munich.

Research papers and reviews are presented that deal with MNPs in various - mostly biomedical - applications. Based on the scientific background of the guest editors, a focus of this theme issue is magnetic drug targeting, in particular magnetically guided and enhanced nucleic acid delivery, also known as magnetofection. Considerable progress in this particular field has been accomplished during the last decade. This focus is not intended to neglect the formidable achievements with magnetic particles in other biomedical applications, such as cell tracking and positioning, magnetic cell separation, imaging and diagnostics, theranostics, magnetic actuation of cellular functions, AC magnetic field hyperthermia, etc. Most contributions to this theme issue report on applications of magnetic particles as opposed to theoretical / physical considerations. However, several papers focus on chemical and physical topics implied in the preparation and imaging/detection of MNPs as well as on mathematical models to better understand the physics of  magnetofection.

To see for yourself, see http://www.springerlink.com/content/m042121872283227/


Higher Magnetic Field Frequencies Might Raise Peripheral Nerve Excitation Thresholds

June 06, 2012

Procedures such as MRI, magnetic hyperthermia, and maybe magnetically induced drug release require the application of rapidly changing magnetic fields. Irving Weinberg from Bethesda, MD recently published a study where he shows that increasing the frequency of the fields actually reduces the occurence of peripheral nerve stimulation (PNS). PNS is consistent with Maxwell’s equations that relate changing magnetic fields (i.e., dB/dt) with induced electromotive forces; the switching of magnetic gradient coils can result in the local induction of electrical currents in the human body, leading to PNS which can be unpleasant or even painful if sufficiently strong.

To check out if this is important for your applications and to learn more, check here.


Report from the Magnetic Carrier Meeting 2012

May 29, 2012

The now already 9th International Conference on the Scientific and Clinical Applications of Magnetic Carriers from May 22-26, 2012 was again a wonderful meeting full of great science and lots of interesting talks (76 of them, 6 invited talks and a tutorial). Minneapolis, MN, USA was a perfect location, and Prof. Jian Ping Wang, our host, and his lab organized a seemless program on the beautiful University of Minnesota campus. A highlight of the meeting was the beautiful boat trip on the Mississippi.

If you wonder what all we did - just in case you would like to come to our next meeting - then please check out the details here:
       -  Scientific Program 2012
       -  Posters 2012
       -  BioMax Satellite Symposium 2012


Two Best Paper Awards Available for ICMF-13

May 29, 2012

The 13th International Conference on Magnetic fluids has proposed to give two best paper awards to young researchers below the age of 35 years for the outstanding contributions in the field of ferro fluids research. Deadline for this award is June 30, 2012 and the meeting link is http://icmf13.com.

A brief manuscript containing four A-4 size pages with recent results may be submitted for the evaluation. The format is:
•   Title
•   Author Affiliation
•   Brief Abstract (not more than 50 words.)
•   Introduction
•   Experimental Details
•   Result and discussion
•   Conclusion
You may register yourself to apply for the Young Scientist Award here.


Nanoparticle Growth Observed in TEM for the First Time

May 29, 2012

The real-time dynamics of nano crystal growth via electron microscopy, observing particles
form and then attach to one another in solution
(Science, DOI: 10.1126/science.1219643). Such particle-level knowledge of nanocrystal growth should help scientists better control the synthesis and properties of nanomaterials.

De Yoreo’s team monitored the formation of iron oxy hydroxide nanoparticles. As small particles approach each other during synthesis, they orient so that their crystal lattices match. Once this happens, the tiny crystals accelerate toward one another and join. If small defects form during fusion, the particles shift afterward to fix them.

To see nanocrystals grow via particle-particle attachment, go to http://cenm.ag/grow.


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Last Modified: December 09, 2013 - Magneticmicrosphere.com 2013