MPI is a tomographic imaging technique that detects the magnetic properties of iron-oxide nanoparticles injected into the bloodstream to produce 3D images. The new technology, invented by Philips, and first introduced in a 2005 Nature paper, gave rise to a new era in biological imaging. The first commercial machines to do Magnetic Particle Imaging are now available from Bruker. Check out their assessment of the technology (and advertisement) on their website:
The most recent international meeting about MPI was in Istanbul from March 26-28, 2015. And the next meeting will be in Lübeck, Germany, from March 16-18, 2016. Check out details about earlier and upcoming MPI meetings here:
Magnetic Insight is proud to launch the first webinar series on Magnetic Particle Imaging, a unique, ultra-sensitive, high resolution molecular imaging approach that longitudinally detects nanoparticles regardless of depth. Sign up for all three!
Tuesday June 9, 2015 9:00 PST/ 18:00 CET The Basics of MPI
Tuesday July 7, 2015 9:00 PST/ 18:00 CET Preclinical Applications in MPI
Tuesday August 4, 2015 9:00 PST/ 18:00 CET Nanoparticle Development for MPI Applications
The Central Japan Railway company reports that its magnetic levitation bullet train topped 603 km/h on Tuesday during a test run along a length of test track in the Yamanashi prefecture. This was enough to break its own 12-year-old, 361 mph world record set back in 2003. The train reportedly carried 29 engineers during its run.
Unfortunate is the fact that normal passengers will likely never be able to experience these exhilarating speeds -- unless something goes horribly wrong. The rail company plans to limit the trains to a pokey 313 mph for regular service when they come online in 2027. But even at these speeds, commuters could make it from Tokyo to Nagoya in about 40 minutes (less than half the time today's fastest bullet trains require). The company even has aspirations to export this technology to America -- specifically as a high-speed rail line running between New York City and Washington DC.
The use of Mossbauer spectroscopy is a simple and direct way to determine the amounts of magnetite and maghemite in an otherwise unknown sample. Quentin Pankhurst et al wrote a nice paper about how to use it and determine magnetite/maghemite weighting directly from the mean isomer shift of the total spectrum, which means that one can apply a simple model-independent curve-fitting methodology. Compared to the older way of using Moessbauer, this takes an awful lot of the work out of the process.
Check out the paper for yourself here.
Wildeboer, Southern and Pankhurst published recently a paper about the reliable measurement of specific absorption rates and intrinsic loss parameters in magnetic hyperthermia. They also carefully reviewed how to cope with non-adiabatic measurement conditions. This paper might very useful for the novice and more experienced user, as they went pretty thoroughly through the methodologies, and have tried to make some recommendations for both the measurement procedure, and the analysis method, that anyone will be able to follow.
Check out this very useful paper here.
Our already 10th International Conference on the Scientific and Clinical Applications of Magnetic Carriers took place in Dresden, Germany from June 10-14, 2014. It was a wonderful gathering of more than 330 participants from 41 countries, where we discussed all the different aspects of magnetic nanoparticles and microspheres, how they can be made, used and applied in new and ever more fascinating ways!
Check out all the details at
The research discussed at the meeting has now been published in full-size peer-reviewed papers in the Journal of Magnetism and Magnetic Materials (JMMM). Check it out here.
In a recent review - called a perspective - Lucia Gutierrez and collaborators wrote a nice discussion of the current state of the art in making magnetic nanoparticles. They write that many different single-core and multi-core magnetic iron oxide nanoparticles are being made for biomedical applications. There are more examples of multi-core magnetic particles than single-core ones, especially since coating of particle aggregates within a matrix will result in multi-core particles. However, it is difficult to control the number of cores, inter-core distances and spatial distribution when generating multi-core particles.
Many parameters of the synthesis procedure may have a strong effect on the particles obtained, including temperature, reagent concentrations, surfactant concentrations, and stirring conditions. This is one of the reasons why scaling-up of some of these synthesis routes is extremely complicated. Indeed, one of the difficulties that particle synthesis faces is in batch-to batch reproducibility. This has led to recent work on alternative reaction platforms that can offer more consistent results. One such platform is the use of microwave irradiation as a heating source.
Check out this interesting paper here.
It is never fun to have to admit to a scientific error. However, it is truly appreciated by people discussing a specific paper and not being able to reproduce something. Ramachandran et al. just published a correction in an upcoming Langmuir paper. They had in an earlier paper reported about highly magnetic metallic nanoparticles. Which at the end turned out to be contaminations with iron, as seen by scanning electron microscopy (SEM) and energy-dispersive X-ray
spectroscopy (EDS) mapping. Thank you for being honest and pointing our magnetic particle community to possible problems with today's highly sensitive analysis methods.
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